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About Tobias Gruber

Tobias obtained a chemistry degree in 2004 and a PhD in organic and supramolecular chemistry in 2008 from the University of Freiberg/Saxony (PhD adviser: Edwin Weber). After one year at the Institute of Pharmaceutical Sciences in the group of Manfred Jung (Freiburg/Breisgau), where Tobias worked on the development of histone deacetylase inhibitors, he moved to the University of Oxford for a postdoctoral stay in the group of Christopher Schofield to perform research in the field of antibiotics. In 2011, Tobias started his independent research career in Braunschweig and moved later back to Freiberg. Since November 2015, Tobias is a Senior Lecturer in the College of Science in Lincoln. His research interests include drug delivery systems for biologically active compounds, medicinal chemistry and crystal engineering. The outcome of this research is of interest to a number other science branches, e.g. Biology and Medicine. Recent research deals with selective receptors for methylammonium ions. These occur as structural motifs in a variety of biological active compounds, e.g. as post-translational methylation of lysine residues in respective proteins or small molecules like acetylcholine, ephedrine or methamphetamine. They have high medicinal relevance, though some are used illicitly. A specific complexation of such compounds is an envisaged basis for sensor active materials, which will open new fields in the field of diagnostics and therapy. A second branch of Tobias’ research provides the basis for a novel synthesis pathway of bicyclic gamma-lactams from the somewhat larger caprolactams. Further elaboration of these synthetic sequences will contribute to the preparation of new antibiotics and lactamase inhibitors to be used against resistant bacteria strains. In the last years Tobias established a network of national and international collaborators. Main scientific partners outside of Lincoln are: Prof Christopher Schofield (Oxford), Prof Dirk Labudde (Mittweida), Dr Ivanhoe Leung (Auckland), Dr Petra Bombicz (Budapest), Dr Richard Hopkinson (Leicester). Currently, I am looking for a Masters student (Home/EU) who is interested to work on a project to synthesize fluorescent macrocycles. Funding is available to cover the tuition fees. The project shall start in September/October 2018. I am always looking for PhD self-financed students who are interested to work in one of the following areas: - Synthesis of fluorescent macrocycles for the recognition of methylammonium ions - Delivery of antimicrobials by supramolecular hosts - Crystallization and polymorphism of APIs Feel also free to email me to discuss projects outside these areas.

Department Responsibilities

Module Leader “Pharmaceutical Materials” Module Leader “Natural Products and Herbal Medicines” Personal tutor

Subject Specialism

Pharmaceutics, organic & supramolecular chemistry, crystallography & polymorphism


  • Associate Fellow of the Higher Education Academy — The Higher Education Academy, 2016
  • Dr. rer. nat. ( = PhD) — University of Freiberg/Saxony (Germany), 2008
  • Dipl.-Chem. ( = MSc in Chemistry) — University of Freiberg/Saxony (Germany), 2004


Biomacromolecules - Reviewer Crystal Growth & Design - Reviewer Journal of Molecular Structure - Reviewer MedChemComm - Reviewer New Journal of Chemistry - Reviewer Physical Chemistry Chemical Physics - Reviewer

Orcid ID


Research in the Lincoln Repository

Professional Affiliations

  • Royal Society of Chemistry — Regular member
  • ‘Liebig-Vereinigung fuer Organische Chemie’ — Regular member
  • German Chemical Society (GDCh) — Regular member