Staff Directory

About Paul Squires

Professor in Biomedical Science (Diabetes & Endocrinology) PhD, BSc, FPhysiol My research into diabetes mellitus, aims to better understand the sub-cellular mechanisms that regulate insulin secretion and action in health and disease. A common theme linking our work is determining how cell-cell adhesion, cell-coupling and cell-to-cell communication synchronise activity and function within the renal nephron and pancreatic islet. RESEARCH CAREER 2014-present Professor of Biomedical Science (Diabetes), University of Lincoln, UK 2010-2014 Reader in Diabetes & Endocrinology, University of Warwick, UK 2005-2010 Senior Lecturer in Molecular Physiology, University of Warwick, UK 2001-2004 Honorary Lecturer, King’s College London, UK 2001-2005 Lecturer in Cellular Signalling, University of Warwick, UK 1997-2001 Diabetes UK, RD Lawrence Research Fellow, King’s College London, UK 1998 EASD/Bayer & Peter Baker Traveling Research Fellow, Uppsala, Sweden 1996-1997 Izaak Walton Killam Research Fellow, University of British Columbia, Vancouver, Canada 1995-1996 Royal Society Traveling Research Fellow, University of British Columbia, Vancouver, Canada 1992-1995 Wellcome Trust Research Fellow, University of Sheffield, UK

Department Responsibilities

Chair - School Pump-priming Scheme Coordinator - UoA3: Allied Health Professions, Dentistry, Nursing and Pharmacy (REF2021) Co-Lead - Diabetes, Metabolism & Inflammation (DMI) Group Co-Lead - Level 4 Master in Biosciences (MBio) programmes Lead - MBio Research Projects (BIO9017M) Member - Human Tissue Act Oversight Group (HTAOG) Member - Lincoln Institute for Health (LIH) Advisory Group Member - School Research Committee Member - School Management Committee

Subject Specialism

Diabetes & Endocrinology

Qualifications

  • Certificate in Post-Compulsory Higher Education — University of Warwick, 2003
  • PhD — University of Sheffield, 1992
  • BSc Physiology — University of Sheffield, 1988

Consultancy

Fellow of the Physiological Society (London) Member of the European Association for the Study of Diabetes (EASD) Member of Diabetes UK (DUK)

Orcid ID

0000-0003-4547-6777

Research Interests

  • Cell-to-cell communication

  • Diabetes

  • Diabetic nephropathy

  • Islet structure-function

Research Projects

  • Cx43 Mediated Regulation Of The Inflammasome, A Therapeutic Target In Diabetic Nephropathy — DRWF in 2018
  • EFSD/Boehringer Ingelheim Research Programme in Microvascular Complications of Diabetes — EFSD in 2017
  • Understanding how remodeling of the ECM and altered cell-substrate interactions facilitate progression of tubulointerstitial fibrosis — Diabetes UK in 2017
  • Determining a role for connexin mediated cell communication in the progression of renal fibrosis in the diabetic kidney — Diabetes UK in 2016
  • Understanding the bioscience of cell-adhesion and membrane dynamics that underpin health — Nigerian Petroleum Technology Development Fund in 2015
  • Developing the Lincolnshire joint research agenda for chronic health conditions (Co-I) — Research Investment Fund in 2015
  • The role of the extracellular matrix and cell-substrate interactions in human proximal tubule cells — EFSD/Janssen Kidney Award in 2015
  • Does reorganization of the ECM promote a loss of phenotypic stability in diabetic nephropathy? — WPH Charitable Trust in 2014
  • Cyclosporin A and fibrosis: implications for graft survival. — RDF University of Warwick in 2013
  • Special K and urological complications of ketamine abuse. — The Rosetree Trust in 2013
  • AFM single-cell force spectroscopy: determining the functional role of cell-cell adhesion and membrane dynamics in diabetes. — Diabetes UK in 2012
  • The importance of cell-to-cell contact in diabetic nephropathy: identifying potential novel targets for therapeutic intervention. — WPH Charitable Trust in 2012
  • The effect of TGF-beta on cell-adhesion, cell coupling and cell communication in the kidney. — EFSD/Janssen Kidney Award in 2011
  • The effect of TGF-beta on connexin-mediated signalling: a role in diabetic nephropathy. — Diabetes UK in 2011
  • A role for C-peptide in alleviating diabetic nephropathy — DRWF in 2010
  • Maintenance of E-cadherin , cell adhesion and cell coupling in diabetic nephropathy: a role for C-peptide — University of Warwick Strategic Award in 2010
  • The extracellular calcium-sensing receptor and paracrine signaling in the islet — Diabetes UK in 2010

Research in the Lincoln Repository


PhD Supervisor

Director of Research, Supervision.

Degree Responsibilities

  • Joint Programme Lead - Master of Biosciences (MBio) Level 4 — 2015 to Present

Module Responsibilities

  • Module Lead - BIO9017M MBio Research Project (Level 4) — 2015 to Present
  • Workshop - BIO9018M MBio Research Techniques (Level 4) — 2015 to Present
  • Lectures - BMS2013M Introduction to Clinical Biochemistry (Level 2) — 2015 to Present
  • Lectures - BMS1072M Anatomy & Physiology (Level 1) — 2015 to Present
  • Lectures - BGY3002M Genetics & Bioethics (Level 3) — 2017 to Present
  • Supervisor - BGY3003M Life Science Research Projects (Level 3) — 2015 to Present
  • Tutor - BMS3034M (Level 3) — 2015 to Present
  • Tutor - BMS2018M (Level 2) — 2015 to Present
  • Tutor - BMS1008M (Level 1) — 2015 to Present

Professional Affiliations

  • Physiological Society — Fellow & Departmental Representative (2009-present)
  • Diabetes UK (DUK) — Research Advisory Board member (2005-2013)
  • Diabetes Research & Wellness Foundation (DRWF) — Research Advisory Board member (2010-2016)
  • Diabetes Wellness Network Sverige (DWNS) — Research Advisory Board member (2016-present)
  • European Foundation for the Study of Diabetes (EFSD) — Research Advisory Board member (2012, 2014)
  • Wallenberg Academy Fellowships, Sweden — External Assessor, Grant Reviewer (2018)
  • Diabetes UK (DUK) — RD Lawrence Research Panel member (2013)
  • Diabetes UK (DUK) — Studentship Panel member (2015)
  • King's College London — External Examiner MSc Program in Biomedicine & Molecular Science Research (2006-2010)
  • University of Ulster — External Examiner BSc Program in Biomedical Science (2015-2018)
  • Peninsula College of Medicine & Dentistry — External Assessor Periodic Review (2012)
  • University of Ulster, Biomedical Science — External Assessor Periodic Review (2013)
  • Manchester MMU, Biomedical & Healthcare Science — External Assessor Periodic Review (2017)