Prof Paul Squires

    Professor in Biomedical Science / Programme Leader

    School of Life Sciences
    College of Science

    About Paul Squires

    Professor in Biomedical Science (Diabetes & Endocrinology)

    My research into diabetes mellitus, aims to better understand the sub-cellular mechanisms that regulate insulin secretion and action in health and disease. A common theme linking our work is determining how cell-cell adhesion, cell-coupling and cell-to-cell communication synchronise activity and function within the renal nephron and pancreatic islet.

    For more details see: https://www.lincoln.ac.uk/home/lifesciences/research/molecularbasisofdisease/diabetesresearch/

    RESEARCH CAREER
    2014-present Professor of Biomedical Science (Diabetes), University of Lincoln, UK
    2010-2014 Reader in Diabetes & Endocrinology, University of Warwick, UK
    2005-2010 Senior Lecturer in Molecular Physiology, University of Warwick, UK
    2001-2004 Honorary Lecturer, King’s College London, UK
    2001-2005 Lecturer in Cellular Signalling, University of Warwick, UK
    1997-2001 Diabetes UK, RD Lawrence Research Fellow, King’s College London, UK
    1998 EASD/Bayer & Peter Baker Traveling Research Fellow, Uppsala, Sweden
    1996-1997 Izaak Walton Killam Research Fellow, University of British Columbia, Vancouver, Canada
    1995-1996 Royal Society Traveling Research Fellow, University of British Columbia, Vancouver, Canada
    1992-1995 Wellcome Trust Research Fellow, University of Sheffield, UK

    Department Responsibilities

    Member of the Lincoln Institute for Health (LIH) Advisory Group
    Member of the School Research Committee
    Member of the School Management Committee
    Member of the Health & Safety Committee
    Chair of School Pump-priming Scheme
    Joint Lead for the Master in Biosciences (MBio) programmes
    Module Lead for MBio Research Projects

    Subject Specialism

    Diabetes & Endocrinology

    Qualifications

    • Certificate in Post-Compulsory Higher Education — University of Warwick, 2003
    • PhD — University of Sheffield, 1992
    • BSc Physiology — University of Sheffield, 1988

    Professional Affiliations

    External Activities and Consultancy

    RESEARCH ADVISORY BOARD MEMBERSHIP:
    2005-2013 Diabetes UK (DUK) Main panel.
    2010-2016 Diabetes Research & Wellness Foundation (DRWF).
    2013 Diabetes UK (DUK) RD Lawrence Fellowship panel
    2012, 2014 European Foundation for the Study of Diabetes (EFSD).
    2015 Diabetes UK (DUK) Studentship Panel.
    2016-present European Diabetes Wellness Network (Sweden).

    MEMBERSHIP OF LEARNED SOCIETIES:
    Member of the Physiological Society (London)
    Member of the European Association for the Study of Diabetes (EASD)
    Member of Diabetes UK (DUK)
    Member of the British Society for Endocrinology (BES)

    RESEARCH RELATED ACTIVITIES:
    External Examiner (2006-2010): MSc Program in Biomedicine & Molecular Science Research, KCL
    External Assessor (2012) Periodic Review, Peninsula College of Medicine & Dentistry’s Grad School.
    External Assessor (2013) Periodic Review, Biomedical Science, University of Ulster, Coleraine, NI.
    External Examiner (2015-2018): BSc Program in Biomedical Science, University of Ulster.
    External Assessor (2017) Periodic Review, Biomedical & Healthcare Science, MMU, Manchester.

    Research Interests

    Research Group Memberships

    Research Projects

    • Understanding how remodeling of the ECM and altered cell-substrate interactions facilitate progression of tubulointerstitial fibrosis — Diabetes UK in 2017
    • Determining a role for connexin mediated cell communication in the progression of renal fibrosis in the diabetic kidney — Diabetes UK in 2016
    • Understanding the bioscience of cell-adhesion and membrane dynamics that underpin health — Nigerian Petroleum Technology Development Fund in 2015
    • Developing the Lincolnshire joint research agenda for chronic health conditions (Co-I) — Research Investment Fund in 2015
    • The role of the extracellular matrix and cell-substrate interactions in human proximal tubule cells — EFSD/Janssen Kidney Award in 2015
    • Does reorganization of the ECM promote a loss of phenotypic stability in diabetic nephropathy? — WPH Charitable Trust in 2014
    • Special K and urological complications of ketamine abuse. — The Rosetree Trust in 2013
    • Cyclosporin A and fibrosis: implications for graft survival. — RDF University of Warwick in 2013
    • AFM single-cell force spectroscopy: determining the functional role of cell-cell adhesion and membrane dynamics in diabetes. — Diabetes UK in 2012
    • The importance of cell-to-cell contact in diabetic nephropathy: identifying potential novel targets for therapeutic intervention. — WPH Charitable Trust in 2012
    • The effect of TGF-beta on cell-adhesion, cell coupling and cell communication in the kidney. — EFSD/Janssen Kidney Award in 2011
    • The effect of TGF-beta on connexin-mediated signalling: a role in diabetic nephropathy. — Diabetes UK in 2011

    Research in the Lincoln Repository

    Report a problem with this page