Email
    nholden@lincoln.ac.uk
    Telephone
    01522 88 6014
    Post
    University of Lincoln
    Brayford Pool
    Lincoln
    Lincolnshire
    LN6 7TS
    United Kingdom

    Web Links

    Dr Neil Holden

    Senior Lecturer

    School of Life Sciences
    College of Science

    About Neil Holden

    Senior Lecturer in Life Sciences in the College of Science

    My major research interests revolve around the interaction between anti-inflammatory and pro-inflammatory pathways in inflammatory airway diseases predominantly Asthma and chronic obstructive pulmonary disease (COPD).
    Corticosteroids (aka glucocorticoids) are the mainstay therapy of the inflammatory lung diseases asthma and COPD. In more severe cases of these diseases they are often taken in combination with “reliever” therapies, such as long acting Beta 2 adrenergic receptor agonists (LABA’s), as these combinations have been shown to be more beneficial than corticosteroids alone. However it is not entirely clear the anti-inflammatory molecular mechanisms these drugs activate within the various lung cells.
    I have previously developed a strong interest in proteins who have potential anti-inflammatory activities and whose expression is driven by corticosteroids and/or LABAs.  My current research projects are focused on the interaction of these anti-inflammatory proteins with respiratory viruses, which are the leading causes of exacerbations and therefore morbidity and mortality in asthma and COPD. 

    Department Responsibilities

    Lecturers in various Modules on Virology, Immunology, Respiratory Pharmacology, and Airway Diseases

    Module leader for Medical and Veterinary Microbiology
    Module Leader for Fundamentals of Pharmacology and Toxicology

    Subject Specialism

    Airway Inflammatory Diseases, Asthma & COPD, Virology and Immunology

    Qualifications

    • PhD in Molecular Physiology — The University of Warwick, 2006
    • BSc in Virology with Intercalated Year — The University of Warwick, 2001

    Awards

    • Eric Reid Fund for Methodology — Biochemical Society, 2015
    • Izaac Walton Killam Postdoctoral Fellowship — Killam Trusts, 2008

    Research Interests

    Research in the Lincoln Repository

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