Staff Directory

About Neil Holden

Senior Lecturer in Life Sciences in the College of Science My major research interests revolve around the interaction between anti-inflammatory and pro-inflammatory pathways in Asthma and Chronic Obstructive Pulmonary Disease (COPD). Corticosteroids (aka glucocorticoids) are the main therapy in asthma and COPD. In more severe cases of these diseases they are often taken in combination with “reliever” therapies, such as long acting Beta 2 adrenergic receptor agonists (LABA’s), as these combinations have been shown to be more beneficial than corticosteroids alone. However, the anti-inflammatory molecular mechanisms these drugs activate within the various lung cells is complex, involving new gene synthesis (transactivation) I have previously developed a strong interest in proteins who have potential anti-inflammatory activities and whose expression is driven by corticosteroids and/or LABAs.  My current research projects are focused on the interaction of these anti-inflammatory proteins with respiratory viruses (in particular Respiratory Syncytial Virus), which are the leading causes of exacerbations and therefore morbidity and mortality in asthma and COPD. 

Department Responsibilities

Lecturers in various Modules on Virology, Immunology, Respiratory Pharmacology, and Airway Diseases Student Engagement Lead Module leader for Medical and Veterinary Microbiology Module leader for Fundamentals of Pharmacology and Toxicology Module leader for Molecular Virology (MSc Microbiology)

Subject Specialism

Airway Inflammatory Diseases (Asthma & COPD) and Virology


  • PGCLTHE — The University of Lincoln, 2016
  • PhD in Molecular Physiology — The University of Warwick, 2006
  • BSc in Virology with Intercalated Year — The University of Warwick, 2001


  • Eric Reid Fund for Methodology — Biochemical Society,
  • Izaac Walton Killam Postdoctoral Fellowship — Killam Trusts,

Orcid ID


Research Interests

  • Asthma

  • beta 2 adrenoceptor agonists

  • COPD

  • Corticosteroids

  • Inflammation

  • Respiratory Syncytial Virus

  • Viruses

Research Groups Memberships

  • Diabetes, Metabolism and Inflammation

Research in the Lincoln Repository

Professional Affiliations