Staff Directory

About Mike Christie

Dr Christie obtained a BSc degree in Biochemistry at University College London in 1978.  He joined Dr Steve Ashcroft and Prof Sir Philip Randle at the University of Oxford, where he acquired an interest in the pathophysiology of the pancreatic beta cell.  For his PhD, Dr Christie studied the role of calmodulin and cyclic AMP-dependent protein kinases in the regulation of insulin secretion. In 1985 he moved to the Hagedorn Research Laboratories, Copenhagen, with Steinunn Baekkeskov and Ake Lernmark, where his interests turned to the targets of the autoimmune response that cause the destruction of the insulin-secreting beta cell in Type 1 diabetes.  Moving to Toronto, then King’s College London, he showed that autoimmunity was directed to multiple islet proteins, identified one of these as the secretory granule protein, IA-2, and, together with the groups of Gian Franco Bottazzo, Edwin Gale and Anette Ziegler, demonstrated that a combination of antibodies to the multiple targets of autoimmunity provides the best predictor of future Type 1 diabetes development.  He joined the University of Lincoln as Reader in Biomedical Sciences in July 2015, where he is investigating the role that B-cells play in promoting pathogenic T-cell responses in the disease, with a goal of developing procedures to modify the activity of islet antigen-specific B-cells as a preventative therapy for Type 1 diabetes.

Department Responsibilities

Chair, University Radiation Safety Committee Vice Chair, School Athena SWAN Committee School REF Co-ordinator Member School Research Committee Module Co-ordinator: Biochemistry & Metabolism

Subject Specialism

Pathophysiology of the pancreatic beta cell

Qualifications

  • PhD — University of London, 1985
  • BSc in Biochemistry — University College London, 1978

Awards

  • University Research Fellowship — Royal Society,
  • Charles H Best Fellowship — University of Toronto,

Orcid ID

0000-0001-5192-3196

Research Interests

  • Immunology of Type 1 diabetes;

  • Pancreatic islet development and function;

  • Regulation of insulin secretion

Research Groups Memberships

  • Molecular Basis of Disease

Research Projects

  • Preclinical testing of IA-2-IgG Fc chimeric proteins for antigen-specific B-cell depletion therapy of Type 1 diabetes. — awarded £146761 by Diabetes UK in 2015
  • Identification of a novel neuroendocrine autoantigen in type 1 diabetes. — awarded £9510 by Society for Endocrinology in 2013
  • Identification of diabetes-associated epitopes by NMR. Project grant. — awarded £14900 by Diabetes UK in 2013
  • Antigen-specific B-cells as targets of immune intervention therapy for Type 1 diabetes. — awarded £70960 by King’s College London Graduate School in 2012
  • Roles of HLA and B-cells in the regulation of pro- and anti-inflammatory T-cell responses to the IA-2 autoantigen in Type 1 diabetes. Project grant.  — awarded £236900 by Diabetes UK in 2012
  • Relationships between antibody and T-cell responses to the IA-2 autoantigen. project grant.  — awarded £235801 by Juvenile Diabetes Research Foundation in 2008
  • Anti-idiotypic antibodies in the autoimmune response to the IA-2 autoantigen in type 1 diabetes. — awarded £78000 by European Foundation for the Study of Diabetes in 2008
  • Detrimental effects of maternal high fat diet on islet development and function in offspring and protection by vitamin E — awarded £87374 by Diabetes UK in 2006

Research in the Lincoln Repository