- McLaughlin, Kerry A. and Richardson, Carolyn C. and Ravishankar, Aarthi and Brigatti, Cristina and Liberati, Daniela and Lampasona, Vito and Piemonti, Lorenzo and Morgan, Diana and Feltbower, Richard G. and Christie, Michael R. (2016) Identification of tetraspanin-7 as a target of autoantibodies in type 1 diabetes. Diabetes, 65 (6). pp. 1690-1698. ISSN 0012-1797
- Christie, Michael (2016) Delving into the Type 1 diabetic islet: evidence that B-cell infiltration of islets is linked to local hyperimmunity and accelerated progression to disease. Diabetes, 65 (5). pp. 1146-1148. ISSN 0012-1797
- Richardson, Carolyn and McLaughlin, Kerry and Morgan, Diana and Feltbower, Richard and Christie, Michael (2016) Influence of HLA-DR and -DQ alleles on autoantibody recognition of distinct epitopes within the juxtamembrane domain of the IA-2 autoantigen in type 1 diabetes. Diabetologia, 59 (2). pp. 334-340. ISSN 0012-186X
- Catani, Mara and Walther, Denise and Christie, Michael and McLaughlin, Kerry and Bonifacio, Ezio and Eugster, Anne (2015) Isolation of human monoclonal autoantibodies derived from pancreatic lymph node and peripheral blood B cells of islet autoantibody-positive patients. Diabetologia . ISSN 0012-186X
- Boag, Alisdair and Christie, Michael and McLaughlin, Kerry and Syme, Harriet and Graham, Peter and Catchpole, Brian (2015) Autoantibodies against cytochrome P450 side-chain cleavage enzyme in dogs (Canis lupus familiaris) affected with hypoadrenocorticism (Addison’s Disease). PloS One, 10 (11). ISSN 1932-6203
- McLaughlin, Kerry A. and Richardson, Carolyn C. and Williams, Stefan and Bonifacio, Ezio and Morgan, Diana and Feltbower, Richard G. and Powell, Michael and Rees Smith, Bernard and Furmaniak, Jadwiga and Christie, Michael R. (2015) Relationships between major epitopes of the IA-2 autoantigen in Type 1 diabetes: implications for determinant spreading. Clinical Immunology, 160 (2). pp. 226-236. ISSN 1521-6616
- Richardson, C. C. and To, K. and Foot, V. L. and Hauge-Evans, A. C. and Carmignac, D. and Christie, Michael (2015) Increased perinatal remodelling of the pancreas in somatostatin-deficient mice: Potential role of transforming growth factor-beta signalling in regulating beta cell growth in early life. Hormone and Metabolic Research, 47 (1). pp. 56-63. ISSN 0018-5043
- McLaughlin, Kerry A. and Gulati, Kavita and Richardson, Carolyn C. and Morgan, Diana and Bodansky, H. Jonathan and Feltbower, Richard G. and Christie, Michael (2014) HLA-DR4-associated T and B cell responses to specific determinants on the IA-2 autoantigen in type 1 diabetes. Journal of Immunology, 193 (9). pp. 4448-4456. ISSN 0022-1767
- Richardson, Carolyn C. and Dromey, Jame A. and McLaughlin, Kerry A. and Morgan, Diana and Bodansky, H. Jonathan and Feltbower, Richard G. and Barnett, Anthony H. and Gill, Geoffrey V. and Bain, Steven C. and Christie, Michael R. (2013) High frequency of autoantibodies in patients with long duration type 1 diabetes. Diabetologia, 56 (11). pp. 2538-2540. ISSN 0012-186X
- Richardson, Carolyn C. and McLaughlin, Kerry A. and Brown, Thomas J. and Morgan, Diana and Feltbower, Richard and Powell, Michael and Furmaniak, Jadwiga and Rees Smith, Bernard and Christie, Michael R. (2013) Failure to detect anti-idiotypic antibodies in the autoimmune response to IA-2 in Type 1 diabetes. Autoimmunity, 46 (6). pp. 375-381. ISSN 0891-6934
- Foot, V. L. and Richardson, C. C. and Jefferson, W. and Taylor, P. D. and Christie, Michael R. (2010) Islets in early life are resistant to detrimental effects of a high-fat maternal diet: a study in rats. Hormone and Metabolic Research, 42 (13). pp. 923-929. ISSN 0018-5043
- Weenink, S. M. and Lo, J. and Stephenson, C. R. and McKinney, P. A. and Ananieva-Jordanova, R. and Rees Smith, B. and Furmaniak, J. and Tremble, J. M. and Bodansky, H. J. and Christie, Michael R. (2009) Autoantibodies and associated T-cell responses to determinants within the 831-860 region of the autoantigen IA-2 in Type 1 diabetes. Journal of Autoimmunity, 33 (2). pp. 147-154. ISSN 0896-8411
- Hauge-Evans, A. C. and King, A. J. and Carmignac, D. and Richardson, C. C. and Robinson, I. C. A. F. and Low, M. J. and Christie, M. R. and Persaud, S. J. and Jones, P. M. (2009) Somatostatin secreted by islet δ-Cells fulfills multiple roles as a paracrine regulator of islet function. Diabetes, 58 (2). pp. 403-411. ISSN 0012 1797
- Davison, L. J. and Weenink, S. M. and Christie, Michael R. and Herrtage, M. E. and Catchpole, B. (2008) Autoantibodies to GAD65 and IA-2 in canine diabetes mellitus. Veterinary Immunology and Immunopathology, 126 (1-2). pp. 83-90. ISSN 0165-2427
- Oak, Shilpa and Gilliam, Lisa K. and Landin-Olsson, Mona and Torn, Carina and Kockum, Ingrid and Pennington, Christina R. and Rowley, Merrill J. and Christie, Michael R. and Banga, J. Paul and Hampe, Christiane S. (2008) The lack of anti-idiotypic antibodies, not the presence of the corresponding autoantibodies to glutamate decarboxylase, defines type 1 diabetes. Proceedings of the National Academy of Sciences of the United States of America, 105 (14). pp. 5471-5476. ISSN 0027-8424
- Samuelsson, A.-M. and Matthews, P. A. and Argenton, M. and Christie, M. R. and McConnell, J. M. and Jansen, E. H. J. M. and Piersma, A. H. and Ozanne, S. E. and Twinn, D. F. and Remacle, C. and Rowlerson, A. and Poston, L. and Taylor, P. D. (2008) Diet-induced obesity in female mice leads to offspring hyperphagia, adiposity, hypertension, and insulin resistance: a novel murine model of developmental programming. Hypertension, 51 (2). pp. 383-392. ISSN 0194-911X
- Zhao, Min and Amiel, Stephanie A. and Christie, Michael R. and Muiesan, Paolo and Srinivasan, Parthi and Littlejohn, Wendy and Rela, Mohamed and Arno, Matthew and Heaton, Nigel and Huang, Guo Cai (2007) Evidence for the presence of stem cell-like progenitor cells in human adult pancreas. Journal of Endocrinology, 195 (3). pp. 407-414. ISSN 0022-0795
- Richardson, C .C. and Hussain, K. and Jones, P. M. and Persaud, S. and Lobner, K. and Boehm, A. and Clark, A. and Christie, Michael R. (2007) Low levels of glucose transporters and K+ ATP channels in human pancreatic beta cells early in development. Diabetologia, 50 (5). pp. 1000-1005. ISSN 0012-186X
- Hauge-Evans, A. C. and Richardson, C. C. and Milne, H .M. and Christie, Michael R. and Persaud, S. J. and Jones, P .M. (2006) A role for kisspeptin in islet function. Diabetologia, 49 (9). pp. 2131-2135. ISSN 0012-186X
- Brereton, Helen C. and Carvell, Melanie J. and Asare-Anane, Henry and Roberts, Graham and Christie, Michael R. and Persaud, Shanta J. and Jones, Peter M. (2006) Homotypic cell contact enhances insulin but not glucagon secretion. Biochemical and Biophysical Research Communications, 344 (3). pp. 995-1000. ISSN 0006-291X
- Piquer, Sandra and Valera, Lionel and Lampasona, Vito and Jardin-Watelet, Benedicte and Roche, Stephanie and Granier, Claude and Roquet, Francoise and Christie, Michael R. and Giordano, Tiziana and Malosio, Maria-Luisa and Bonifacio, Ezio and Laune, Daniel (2006) Monoclonal antibody 76F distinguishes IA-2 from IA-2β and overlaps an autoantibody epitope. Journal of Autoimmunity, 26 (3). pp. 215-222. ISSN 0896-8411
- Zhao, M. and Amiel, S. A. and Christie, Michael R. and Rela, M. and Heaton, N. and Huang, G. C. (2005) Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia, 48 (10). pp. 2051-2061. ISSN 0012-186X
- Harashima, Shin-ichi and Clark, Anne and Christie, Michael R. and Notkins, Abner Louis (2005) The dense core transmembrane vesicle protein IA-2 is a regulator of vesicle number and insulin secretion. Proceedings of the National Academy of Sciences, 102 (24). pp. 8704-8709. ISSN 0027-8424
- Damanhouri, L. H. and Dromey, J. A. and Christie, Michael R. and Nasrat, H. A. and Ardawi, M. S. M. and Robins, R. A. and Todd, I. (2005) Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients. Diabetic Medicine, 22 (4). pp. 448-452. ISSN 0742-3071
- Li, Jian-Mei and Fan, Lampson M. and Christie, Michael R. and Shah, Ajay M. (2005) Acute tumor necrosis factor alpha signaling via NADPH oxidase in microvascular endothelial cells: Role of p47phox phosphorylation and binding to TRAF4. Molecular and cellular biology, 25 (6). pp. 2320-2330. ISSN 0270-7306, 1098-5549
- Gillespie, Kathleen M. and Bain, Steven C. and Barnett, Anthony H. and Bingley, Polly J. and Christie, Michael R. and Gill, Geoffrey V. and Gale, Edwin A. M. (2004) The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes. The Lancet, 364 (9446). pp. 1699-1700. ISSN 0140-6736
- Dromey, Jame A. and Weenink, Sarah M. and Peters, Gunther H. and Endl, Josef and Tighe, Patrick J. and Todd, Ian and Christie, Michael R. (2004) Mapping of epitopes for autoantibodies to the type 1 diabetes autoantigen IA-2 by peptide phage display and molecular modeling: overlap of antibody and T cell determinants. Journal of Immunology, 172 (7). pp. 4084-4090. ISSN 0022-1767
- Huang, Guo Cai and Zhao, Min and Jones, Peter and Persaud, Shanta and Ramracheya, Reshma and Lobner, Kristian and Christie, Michael R. and Banga, J. Paul and Peakman, Mark and Sirinivsan, Parthi and Rela, Mohammed and Heaton, Nigel and Amiel, Stephanie (2004) The development of new density gradient media for purifying human islets and islet-quality assessments. Transplantation, 77 (1). pp. 143-145. ISSN 0041-1337
- Lobner, Kristian and Steinbrenner, Holger and Roberts, Graham A and Ling, Zhidong and Huang, Guo-Cai and Piquer, Sandra and Pipeleers, Daniel G and Seissler, Jochen and Christie, Michael R. (2002) Different regulated expression of the tyrosine phosphatase-like proteins IA-2 and phogrin by glucose and insulin in pancreatic islets. Relationship to development of insulin secretory responses in early life. Diabetes, 51 (10). pp. 2982-2988. ISSN 0012-1797
- Christie, Michael R. and Molvig, Jens and Hawkes, Charlotte J. and Carstensen, Bendix and Mandrup-Poulsen, Thomas (2002) IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporin. Diabetes Care, 25 (7). pp. 1192-1197. ISSN 0149-5992
- Bearzatto, Massimo and Naserke, Heike and Piquer, Sandra and Koczwara, Kerstin and Lampasona, Vito and Williams, Alistair and Christie, Michael R. and Bingley, Polly J. and Ziegler, Annette-G. and Bonifacio, Ezio (2002) Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. Journal of Immunology, 168 (8). pp. 4202-4208. ISSN 0022-1767
- Winnock, Frederic and Christie, Michael R. and Batstra, Manou R. and Aanstoot, Henk-Jan and Weets, Ilse and Decochez, Katelijn and Jopart, Philippe and Nicolaij, Dany and Gorus, Frans K. (2001) Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre)type 1 diabetes: Association with IA-2 and islet cell autoantibodies. Diabetes Care, 24 (7). pp. 1181-1186. ISSN 0149-5992
- Roberts, Caroline and Roberts, Graham A. and Lobner, Kristian and Bearzatto, Massimo and Clark, Anne and Bonifacio, Ezio and Christie, Michael R. (2001) Expression of the protein tyrosine phosphatase-like protein IA-2 during pancreatic islet development. Journal of Histochemistry and Cytochemistry, 49 (6). pp. 767-775. ISSN 0022-1554
- Gylling, Mikhail and Tuomi, Tiinamaija and Bjorses, Petra and Kontiainen, Sirkka and Partanen, Jukka and Christie, Michael R. and Knip, Mikael and Perheentupa, Jaakko and Miettinen, Aaro (2000) β-Cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Journal of Clinical Endocrinology and Metabolism, 85 (12). pp. 4434-4440. ISSN 0021-972X
- Kolm-Litty, Verena and Berlo, Suzanne and Bonifacio, Ezio and Bearzatto, Massimo and Engel, Alfred M. and Christie, Michael R. and Ziegler, Annette-G. and Wild, Thomas and Endl, Josef (2000) Human monoclonal antibodies isolated from type I diabetes patients define multiple epitopes in the protein tyrosine phosphatase-like IA-2 antigen. Journal of Immunology, 165 (8). pp. 4676-4684. ISSN 0022-1767
- Hawkes, C. J. and Schloot, N. C. and Marks, J. and Willemen, S. J. M. and Drijfhout, J. W. and Mayer, E. K. and Christie, M. R. and Roep, B. O. (2000) T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes. Diabetes, 49 (3). pp. 356-366. ISSN 0012-1797
- Christie, Michael (1999) Islet proteins implicated in pathogenesis of type 1 diabetes mellitus. Advances in Molecular and Cell Biology, 29 (C). pp. 75-100. ISSN 1569-2558
- Morgenthaler, N. G. and Löbner, K. and Morgenthaler, U. Y. and Christie, M. R. and Seissler, J. and Scherbaum, W. A. (1998) Recombinant IA-2 expressed in E. coli can be used for the routine detection of autoantibodies in type-I diabetes. Hormone and Metabolic Research, 30 (9). pp. 559-564. ISSN 0018-5043
- Bonifacio, E. and Christie, M. R. (1997) Islet cell antigens in the prediction and prevention of insulin-dependent diabetes mellitus. Annals of Medicine, 29 (5). pp. 405-412. ISSN 0785-3890
- Hatfield, E. C. I. and Hawkes, C. J. and Payton, M. A. and Christie, Michael R. (1997) Cross reactivity between IA-2 and phogrin/IA-2β in binding of autoantibodies in IDDM. Diabetologia, 40 (11). pp. 1327-1333. ISSN 0012-186X
- Hawa, M. and Rowe, R. and Lan, M. S. and Notkins, A. L. and Pozzilli, P. and Christie, M. R. and Leslie, R. D. G. (1997) Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes. Diabetes, 46 (8). pp. 1270-1275. ISSN 0012-1797
- Tremble, Jennifer and Morgenthaler, Nils G. and Vlug, Arjen and Powers, Alvin C. and Christie, Michael R. and Scherbaum, Werner A. and Banga, J. Paul (1997) Human B cells secreting immunoglobulin G to glutamic acid decarboxylase- 65 from a nondiabetic patient with multiple autoantibodies and Graves' disease: a comparison with those present in type 1 diabetes. Journal of Clinical Endocrinology and Metabolism, 82 (8). pp. 2664-2670. ISSN 0021-972X
- Christie, Michael R. and Roll, Ursula and Payton, Mark A. and Hatfield, Emma C. I. and Ziegler, Annette- G. (1997) Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care, 20 (6). pp. 965-970. ISSN 0149-5992
- Gorus, F. K. and Goubert, P. and Semakula, C. and Vandewalle, C. L. and De Schepper, J. and Scheen, A. and Christie, Michael R. and Pipeleers, D. G. (1997) IA-2-autoantibodies complement GAD65-autoantibodies in new-onset IDDM patients and help predict impending diabetes in their siblings. Diabetologia, 40 (1). pp. 95-99. ISSN 0012-186X
- Morgenthaler, N. G. and Seissler, J. and Achenbach, P. and Glawe, D. and Payton, M. and Meinck, H.-M. and Christie, Michael R. and Scherbaum, W. A. (1997) Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome. Autoimmunity, 25 (4). pp. 203-211. ISSN 0891-6934
- Christie, M. R. (1996) Islet cell autoantigens in type 1 diabetes. European Journal of Clinical Investigation, 26 (10). pp. 827-838. ISSN 0014-2972
- Hawkes, C. J. and Wasmeier, C. and Christie, M. R. and Hutton, J. C. (1996) Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase- like protein (phogrin) related to IA-2. Diabetes, 45 (9). pp. 1187-1192. ISSN 0012-1797
- Roll, U. and Christie, M. R. and Fuchtenbusch, M. and Payton, M. A. and Hawkes, C. J. and Ziegler, A.-G. (1996) Perinatal autoimmunity in offspring of diabetic parents: the German multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45 (7). pp. 967-973. ISSN 0012-1797
- Bonifacio, E. and Christie, M. R. (1996) Tyrosine phosphatase-like proteins as autoantigens in insulin-dependent diabetes mellitus: the targets for 37/40k antibodies. Diabetes, Nutrition and Metabolism - Clinical and Experimental, 9 (4). pp. 183-187. ISSN 0394-3402
- Seissler, J. and Morgenthaler, N. G. and Achenbach, P. and Lampeter, E .F. and Glawe, D. and Payton, M. and Christie, Michael and Scherbaum, W. A. (1996) Combined screening for antoantibodies to IA-2 and antibodies to glutamic acid decarboxylase in first degree relatives of patients with IDDM. Diabetologia, 39 (11). pp. 1351-1356. ISSN 0012-186X
- Payton, M. A. and Hawkes, C. J. and Christie, M. R. (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). Journal of Clinical Investigation, 96 (3). pp. 1506-1511. ISSN 0021-9738
- Bingley, P. J. and Christie, M. R. and Bonifacio, E. and Bonfanti, R. and Shattock, M. and Fonte, M.-T. and Bottazzo, G.-F. and Gale, E. A. M. (1994) Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes, 43 (11). pp. 1304-1310. ISSN 0012-1797
- Christie, M. R. and Genovese, S. and Cassidy, D. and Bosi, E. and Brown, T. J. and Lai, M. and Bonifacio, E. and Bottazzo, G. F. (1994) Antibodies to islet 37k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity. Diabetes, 43 (10). pp. 1254-1259. ISSN 0012-1797
- Wagner, R. and McNally, J. M. and Bonifacio, E. and Genovese, S. and Foulis, A. and McGill, M. and Christie, M. R. and Betterle, C. and Bosi, E. and Bottazzo, G. F. (1994) Lack of immunohistological changes in the islets of nondiabetic, autoimmune, polyendocrine patients with β-Selective GAD-specific islet cell antibodies. Diabetes, 43 (7). pp. 851-856. ISSN 0012-1797
- Lampeter, E. F. and Kolb, H. and Seifert, I. and Lohmann, D. and Heise, J. W. and Bertrams, J. and Christie, Michael and Kolb-Bachofen, V. (1994) Inflammatory islet damage in patients bearing HLA-DR 3 and/or DR 4 haplotypes does not lead to islet autoimmunity. Diabetologia, 37 (5). pp. 471-475. ISSN 0012-186X
- Wagner, R. and Genovese, S. and Bosi, E. and Becker, F. and Bingley, P. J. and Bonifacio, E. and Miles, K. A. and Christie, Michael and Bottazzo, G. F. and Gale, E. A. M. (1994) Slow metabolic deterioration towards diabetes in islet cell antibody positive patients with autoimmune polyendocrine disease. Diabetologia, 37 (4). pp. 365-371. ISSN 0012-186X
- Roll, U. and Christie, M. R. and Standl, E. and Ziegler, A.-G. (1994) Associations of anti-GAD antibodies with islet cell antibodies and insulin autoantibodies in first-degree relatives of type I diabetic patients. Diabetes, 43 (1). pp. 154-160. ISSN 0012-1797
- Christie, M. R. and Hollands, J. A. and Brown, T. J. and Michelsen, B. K. and Delovitch, T. L. (1993) Detection of pancreatic islet 64,000 Mr autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylase. Journal of Clinical Investigation, 92 (1). pp. 240-248. ISSN 0021-9738
- Christie, M. R. (1993) Characterization of distinct islet protein auto antigens associated with type 1 diabetes. Autoimmunity, 15 (s1). pp. 1-3. ISSN 0891-6934
- Christie, M. R. and Tun, R. Y. M. and Lo, S. S. S. and Cassidy, D. and Brown, T. J. and Hollands, J. and Shattock, M. and Bottazzo, G. F. and Leslie, R. D. G. (1992) Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: studies with identical twins. Diabetes, 41 (7). pp. 782-787. ISSN 0012-1797
- Christie, Michael and Brown, T. J. and Cassidy, D. (1992) Binding of antibodies in sera from Type 1 (insulin-dependent) diabetic patients to glutamate decarboxylase from rat tissues. Evidence for antigenic and non-antigenic forms of the enzyme. Diabetologia, 35 (4). pp. 380-384. ISSN 0012-186X
- Bottazzo, G. F. and Genovese, S. and Bosi, E. and Dean, B. M. and Christie, M. R. and Bonifacio, E. (1991) Novel considerations on the antibody/autoantigen system in type I (insulin-dependent) diabetes mellitus. Annals of Medicine, 23 (4). pp. 453-461. ISSN 0785-3890
- Christie, M. R. and Vohra, G. and Champagne, P. and Daneman, D. and Delovitch, T. L. (1990) Distinct antibody specificities to a 64-kD islet cell antigen in Type 1 diabetes as revealed by trypsin treatment. Journal of Experimental Medicine, 172 (3). pp. 789-794. ISSN 0022-1007
- Christie, M. R. and Daneman, D. and Champagne, P. and Delovitch, T. L. (1990) Persistence of serum antibodies to 64,000-Mr islet cell protein after onset of type I diabetes. Diabetes, 39 (6). pp. 653-656. ISSN 0012-1797
- Christie, M. R. and Pipeleers, D. G. and Lernmark, A. and Baekkeskov, S. (1990) Cellular and subcellular localization of an Mr 64,000 protein autoantigen in insulin-dependent diabetes. Journal of Biological Chemistry, 265 (1). pp. 376-381. ISSN 0021-9258
- Christie, Michael and Landin-Olsson, M. and Sundkvist, G. and Dahlquist, G. and Lernmark, A. and Baekkeskov, S. (1988) Antibodies to a Mr-64000 islet cell protein in Swedish children with newly diagnosed Type 1 (insulin-dependent) diabetes. Diabetologia, 31 (8). pp. 597-602. ISSN 0012-186X
- Hughes, S. J. and Christie, M. R. and Ashcroft, S. J. H. (1987) Potentiators of insulin secretion modulate Ca2+ sensitivity in rat pancreatic islets. Molecular and Cellular Endocrinology, 50 (3). pp. 231-236. ISSN 0303-7207
- Christie, M. R. and Ashcroft, S. J. H. (1985) Substrates for cyclic AMP-dependent protein kinase in islets of Langerhans. Studies with forskolin and catalytic subunit. Biochemical Journal, 227 (3). pp. 727-736. ISSN 0264-6021
- Harrison, D. E. and Christie, Michael and Gray, D. W. R. (1985) Properties of isolated human islets of langerhans: insulin secretion, glucose oxidation and protein phosphorylation. Diabetologia, 28 (2). pp. 99-103. ISSN 0012-186X
- Harrison, D. E. and Ashcroft, S. J. H. and Christie, M. R. and Lord, J. M. (1984) Protein phosphorylation in the pancreatic B-cell. Experientia, 40 (10). pp. 1075-1084. ISSN 0014-4754
- Christie, M. R. and Ashcroft, J. H. (1984) Cyclic AMP-dependent protein phosphorylation and insulin secretion in intact islets of Langerhans. Biochemical Journal, 218 (1). pp. 87-99. ISSN 0264-6021
- Christie, M. R. and Harrison, D.E. and Ashcroft, S.J.H. (1982) Cyclic AMP, calmodulin and insulin secretion. Diabetologia, 23 (5). p. 21. ISSN 0012-186X
- Gagliardino, J. J. and Harrison, D. E. and Christie, M. R. and Gagliardino, E. E. and Ashcroft, S. J. (1980) Evidence for the participation of calmodulin in stimulus-secretion coupling in the pancreatic β-cell. Biochemical Journal, 192 (3). pp. 919-927. ISSN 0264-6021
- Grant, A. M. and Christie, M. R. and Ashcroft, S. J. H. (1980) Insulin release from human pancreatic islets in vitro. Diabetologia, 19 (2). pp. 114-117. ISSN 0012-186X
- Ashcroft, S. J. H. and Christie, M. R. (1979) Effects of glucose on the cytosolic ratio of reduced/oxidized nicotinamide adenine dinucleotide phosphate in rat islets of Langerhans. Biochemical Journal, 184 (3). pp. 697-700. ISSN 0264-6021
- Sugden, M. C. and Christie, M. R. and Ashcroft, S. J. H. (1979) Presence and possible role of calcium-dependent regulator (calmodulin) in rat islets of langerhans. FEBS Letters, 105 (1). pp. 95-100. ISSN 0014-5793
Staff Directory
- Last Updated
-
09/10/2017
- mchristie@lincoln.ac.uk
- Telephone
- 01522 83 7434
Dr Mike Christie
Reader
School of Life Sciences
College of Science
About Mike Christie
Dr Christie obtained a BSc degree in Biochemistry at University College London in 1978. He joined Dr Steve Ashcroft and Prof Sir Philip Randle at the University of Oxford, where he acquired an interest in the pathophysiology of the pancreatic beta cell. For his PhD, Dr Christie studied the role of calmodulin and cyclic AMP-dependent protein kinases in the regulation of insulin secretion. In 1985 he moved to the Hagedorn Research Laboratories, Copenhagen, with Steinunn Baekkeskov and Ake Lernmark, where his interests turned to the targets of the autoimmune response that cause the destruction of the insulin-secreting beta cell in Type 1 diabetes. Moving to Toronto, then King’s College London, he showed that autoimmunity was directed to multiple islet proteins, identified one of these as the secretory granule protein, IA-2, and, together with the groups of Gian Franco Bottazzo, Edwin Gale and Anette Ziegler, demonstrated that a combination of antibodies to the multiple targets of autoimmunity provides the best predictor of future Type 1 diabetes development. He joined the University of Lincoln as Reader in Biomedical Sciences in July 2015, where he is investigating the role that B-cells play in promoting pathogenic T-cell responses in the disease, with a goal of developing procedures to modify the activity of islet antigen-specific B-cells as a preventative therapy for Type 1 diabetes.
Department Responsibilities
Chair, University Radiation Safety Committee Vice Chair, School Athena SWAN Committee School REF Co-ordinator Member School Research Committee Module Co-ordinator: Biochemistry & Metabolism
Subject Specialism
Pathophysiology of the pancreatic beta cell
Qualifications
- PhD — University of London, 1985
- BSc in Biochemistry — University College London, 1978
Awards
- University Research Fellowship — Royal Society,
- Charles H Best Fellowship — University of Toronto,
Orcid ID
0000-0001-5192-3196
Research Interests
Immunology of Type 1 diabetes;
Pancreatic islet development and function;
Regulation of insulin secretion
Research Groups Memberships
- Molecular Basis of Disease
Research Projects
- Preclinical testing of IA-2-IgG Fc chimeric proteins for antigen-specific B-cell depletion therapy of Type 1 diabetes. — awarded £146761 by Diabetes UK in 2015
- Identification of a novel neuroendocrine autoantigen in type 1 diabetes. — awarded £9510 by Society for Endocrinology in 2013
- Identification of diabetes-associated epitopes by NMR. Project grant. — awarded £14900 by Diabetes UK in 2013
- Antigen-specific B-cells as targets of immune intervention therapy for Type 1 diabetes. — awarded £70960 by King’s College London Graduate School in 2012
- Roles of HLA and B-cells in the regulation of pro- and anti-inflammatory T-cell responses to the IA-2 autoantigen in Type 1 diabetes. Project grant. — awarded £236900 by Diabetes UK in 2012
- Relationships between antibody and T-cell responses to the IA-2 autoantigen. project grant. — awarded £235801 by Juvenile Diabetes Research Foundation in 2008
- Anti-idiotypic antibodies in the autoimmune response to the IA-2 autoantigen in type 1 diabetes. — awarded £78000 by European Foundation for the Study of Diabetes in 2008
- Detrimental effects of maternal high fat diet on islet development and function in offspring and protection by vitamin E — awarded £87374 by Diabetes UK in 2006