Staff Directory

About Ishwar Singh

Ishwar Singh is a Reader in Biological Chemistry at the School of Pharmacy, University of Lincoln. Prior to Lincoln, he had held many prestigious fellowships such as the Alexander von Humboldt fellowship, Germany; and Senior Research Fellowship, DANIDA, Denmark and CSIR, India. He is an organic chemist. He is leading ground-breaking research on new classes of antibiotics such as teixobactins. To realise the therapeutic potential of teixobactins, he has made notable seminal contributions such as first highly efficient synthesis of simplified teixobactin analogues, first determination of three dimensional molecular structure of teixobactins, significant breakthrough in simplified design and an efficient synthesis of highly potent teixobactin analogues, with identical or superior potency than natural teixobactin against Multi Drug Resistant Gram positive bacteria such as Methicillin resistant Staphylococcus aureus (MRSA), Enterococcus spp. (vancomycin-resistant enterococci, VRE) and Mycobacterium (TB), first successful treatment of mice using simplified teixobactin against bacterial infections. He is developing new major research programmes focussed on the development of peptides and other small molecules, active against resistant micro-organisms. The other areas of current research are in Biologics delivery, Peptides, Sequence selective DNA cross linking, Nanoparticles modifications for drug delivery and diagnostic applications. His ground-breaking research, focussing on a key priority for antimicrobial resistance has featured on tv, radio, newspaper and electronic media globally. Some examples are BBC Look North TV, BBC Radio Lincolnshire ITV (http://www.itv.com/news/calendar/2018-03-26/breakthrough-on-road-to-superbug-killing-antibiotic/), Daily Mail, The Times, 10 million lives could be lost to superbugs – so how far have we got in the race to beat them? Telegraph (https://www.telegraph.co.uk/health-fitness/body/10-million-lives-could-lost-superbugs-far-have-got-race-beat/) Breakthrough on road to superbug-killing antibiotic http://www.itv.com/news/calendar/2018-03-26/breakthrough-on-road-to-superbug-killing-antibiotic/ Simplified structure eases antibiotic synthesis https://www.chemistryworld.com/news/simplified-structure-eases-antibiotic-synthesis/3007718.article Molecular structure is teixobactin’s pièce de résistance https://www.chemistryworld.com/news/molecular-structure-is-teixobactins-pi%C3%A8ce-de-r%C3%A9sistance/2500349.article September 2018 Global battle waged against super bacteria https://www.chinadailyhk.com/articles/40/192/75/1536920624944.html September 2018 Fighting infections http://geographical.co.uk/magazine/issues/item/2861-september-2018 more in progress......If you wish to sponsor research on antimicrobials, please contact me.

Department Responsibilities

Member of the international committee, Chemistry tutor Personal Tutor Module lead H & S member

Subject Specialism

Antimicrobials, Chemical Biology, Organic Chemitsry,  Bioconjugations, Biologics Delivery, Nucleic Acids and Peptides,

Qualifications

  • PhD — 2004
  • MPhil — 1999
  • MSc — 1997

Awards

  • Immuno-NanoDecoder — Horizon 2020, EU
  • The Royal Society Research Grant Award — Royal Society
  • Alexander von Humboldt Fellowship — AvH Foundation Germany
  • Senior Research Fellowship — CSIR India

Consultancy

Diverse industry

Orcid ID

0000-0001-7822-1063

Research Interests

  • Antimcicrobials

  • Peptides

  • DNA diagnostics

  • Bioconjugations

  • Drug Delivery

  • Biologics

  • Organic synthesis

Research Projects

  • For PhD and Postdoctoral possibilities in our research areas — Please contact me directly if you are motivated and interested. in
  • Biologic Delivery — Fully funded PhD position available. Please see    http://www.findaphd.com/search/ProjectDetai in
  • Broad Spectrum Antimicrobials — RIF in
  • Bioconjugations — in
  • Defining a chemical lexicon for tumour-specific delivery of biologics — Royal Society in
  • Development of Sequence selective DNA-crosslinking Agents — in

Research in the Lincoln Repository


Professional Affiliations

  • Royal Society of Chemistry — Member